Access to the Published Version May Require Journal Subscription. Published with Permission From: the American Physiological Society Ketamine and Xylazine Depress Sensory-evoked Parallel Fiber and Climbing Fiber Responses
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Ketamine and xylazine depress sensory-evoked parallel fiber and climbing fiber responses.
The last few years have seen an increase in the variety of in vivo experiments used for studying cerebellar physiological mechanisms. A combination of ketamine and xylazine has become a particularly popular form of anesthesia. However, because nonanesthetized control conditions are lacking in these experiments, so far there has been no evaluation of the effects of these drugs on the physiologic...
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Cerebellar Purkinje cells have one of the most elaborate dendritic trees in the mammalian CNS, receiving excitatory synaptic input from a single climbing fiber (CF) and from ∼200,000 parallel fibers. The dendritic Ca(2+) signals triggered by activation of these inputs are crucial for the induction of synaptic plasticity at both of these synaptic connections. We have investigated Ca(2+) signalin...
متن کاملAccess to the Published Version May Require Journal Subscription. Published with Permission From: Thomson Reuters
This is an author produced version of a paper published in Drugs of Today. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. "The treatment of neurological diseases under a new light: the importance of optogenetics."
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